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Article

Protonation States of Proton-Sensing Glutamate Residues in Transporter Sialin.

International journal of molecular sciences - 21 May 2026

Wooten Eric, Chon Nara L, Dzhalolov Muhamadjon, Zheng Hongjin, Lin Hai

Abstract excerpt

Sialic acids are a diverse class of widely distributed monosaccharides that are engaged in a wide range of biological processes. Sialin, a sialic acid/proton symporter, transports sialic acid across membranes between the lysosomal lumen and cytosol, playing a critical role in sialin metabolism. Taking advantage of recently published experimental structures of sialin, we report here the first computational study...

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Identifiers

PMID: 42196605
DOI: 10.3390/ijms27104629
PMCID: PMC13207226

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