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Article

Structure-function studies of the SLC17 transporter sialin identify crucial residues and substrate-induced conformational changes.

The Journal of biological chemistry - 18 Jun 2010

Courville Pascal, Quick Matthias, Reimer Richard J

Abstract excerpt

Salla disease and infantile sialic acid storage disorder are human diseases caused by loss of function of sialin, a lysosomal transporter that mediates H(+)-coupled symport of acidic sugars N-acetylneuraminic acid and glucuronic acid out of lysosomes. Along with the closely related vesicular glutamate transporters, sialin belongs to the SLC17 transporter family. Despite their critical role in health and disease,...

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Source

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Identifiers

PMID: 20424173
DOI: 10.1074/jbc.M110.130716
PMCID: PMC2885210

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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