Article

Collagen Density Modulates the Immunosuppressive Functions of Tumor-Associated Macrophages

2019-01-08

Abstract excerpt

Tumor-associated macrophages (TAMs) support tumor growth by suppressing the activity of tumor infiltrating T cells. Consistently, the number of TAMs has been correlated with a poor prognosis of cancer. The immunosuppressive TAMs are also considered a major limitation for the efficacy of cancer immunotherapy. However, the molecular reason behind the acquisition of an immunosuppressive TAM phenotype is still not com...

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Literature Corpus work: 0226b74f-1895-5bde-bba7-31b7319a1ff3
DOI: 10.1101/513986

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