Article

Alzheimer’s Disease Brain Organoids as a Source of Disease-Relevant Amyloid-Beta Oligomers

2026-03-12

Abstract excerpt

Amyloid plaques are a hallmark of Alzheimer’s disease (AD) progression; however, the early stages of plaque formation and the specific amyloid-beta (Aβ) species involved remain difficult to study. While post-mortem tissue provides insight into end-stage mature plaques, therapeutic development requires targeting the earliest Aβ oligomers to arrest plaque formation. Furthermore, inherently toxic soluble Aβ oligomers...

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Literature Corpus work: 1cd06d13-414e-5f66-bd0a-0bee2e305ea2
DOI: 10.64898/2026.03.09.710594

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