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Article

Autophagy

1 Nov 2011

Abstract excerpt

Mammalian target of rapamycin (mTOR) complex 1 (mTORC1), which is activated in tuberous sclerosis complex (TSC) and lymphangioleiomyomatosis (LAM), is a master regulator of cell growth, cellular metabolism, and autophagy. Treatment of TSC and LAM patients with mTORC1 inhibitors partially decreases the size of brain and kidney tumors, and stabilizes pulmonary function. However, the tumors regrow and lung function...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 21997371
DOI: 10.4161/auto.7.11.17652

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