Article

CG7379/ING1 suppress cancer cell invasion by maintaining cell-cell junction integrity

2020-08-23

Abstract excerpt

Approximately 90% of cancer related deaths can be attributed to a tumour’s ability to spread. We have identified CG7379, the fly orthologue of human ING1, as a potent invasion suppressor. ING1 is a type II tumour suppressor with well-established roles in the transcriptional regulation of genes that control cell proliferation, response to DNA damage, oncogene-induced senescence and apoptosis. Recent work suggests a...

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Literature Corpus work: 1c89f6f8-61bd-58c2-82c4-75f0c0a97432
DOI: 10.1101/2020.08.20.255786

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