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Article

Cdk5 in Oncology: Recent Advances and Future Prospects

1 Oct 2017

Abstract excerpt

Selective abrogation of cyclin-dependent kinases (CDK) activity is a highly promising strategy in cancer treatment. The atypical CDK, CDK5 has long been known for its role in neurodegenerative diseases, and is becoming an attractive drug target for cancer therapy. Myriads of recent studies have uncovered that aberrant expression of CDK5 contributes to the oncogenic initiation and progression of multiple solid and...

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PMID: 29076761
DOI: 10.4155/fmc-2017-0097

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