Article

Rescuing functional defects in a zebrafish model of CDKL5 deficiency disorder: Contribution to the identification of new therapeutic compounds

2026-03-16

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in the CDKL5 gene cause CDKL5 deficiency disorder (CDD), a severe neurodevelopmental encephalopathy characterized by a broad range of symptoms, including early-onset seizures, profound motor impairment and dysmorphic facial features. Current treatment options remain limited and largely focus on seizure management, which is often challenging to control, underscoring the critical need f...

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Literature Corpus work: 5c16b5c5-020f-55ce-91b8-bfe4f56793fd
DOI: 10.64898/2026.03.12.711124

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