Article

Systematic search for new HLA alleles in 4195 human 30x WGS samples

2024-06-04

Abstract excerpt

HLA (Human Leukocyte Antigens) is a highly polymorphic locus in the human genome which also has a high clinical significance. New alleles of HLA genes are constantly being discovered but mostly through the efforts of laboratories which primarily focus on HLA typing and are using field-specific experimental and data processing techniques, like enrichment of HLA region in high-throughput sequencing data. Nevertheles...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1c59f09e-b475-5f7b-b477-da66b29b7c85
DOI: 10.1101/2024.05.31.596796

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Systematic search for new HLA alleles in 4195 human 30x WGS samplesDOI 10.1101/2024.05.31.596796Read

NovAT tool-Reliable novel HLA alleles identification from next-generation sequencing data.Semantic proximity Read

Next-Generation Sequencing of the HLA locus: Methods and impacts on HLA typing, population genetics and disease association studies.Semantic proximity Read

Collection and storage of HLA NGS genotyping data for the 17th International HLA and Immunogenetics WorkshopSemantic proximity Read

Progressing towards the complete and thorough characterization of the HLA genes by NGS (or single-molecule DNA sequencing): Consequences, opportunities and challengesSemantic proximity Read

Benchmark of tools for <i>in silico</i> prediction of MHC class I and class II genotypes from NGS dataSemantic proximity Read

Comprehensive HLA Typing from a Current Allele Database Using Next-Generation Sequencing Data.Semantic proximity Read

Benchmark of tools for in silico prediction of MHC class I and class II genotypes from NGS dataSemantic proximity Read

More than 150 novel variants of HLA class I genes detected in German Stem Cell Donor Registry and UCLA International Cell Exchange samples.Semantic proximity Read

16(th) IHIW: extending the number of resources and bioinformatics analysis for the investigation of HLA rare alleles.Semantic proximity Read

The impact of next-generation sequencing technologies on HLA research.Semantic proximity Read

Development of a high-resolution NGS-based HLA-typing and analysis pipeline.Semantic proximity Read

Benchmarking freely available human leukocyte antigen typing algorithms across varying genes, coverages and typing resolutionsSemantic proximity Read