Article

Sphingomyelinase Licensing of Mesenchymal Stromal Cells Alters Lipid and Protein Metabolites for Immunomodulation

2025-07-22

Abstract excerpt

<h4>ABSTRACT</h4> Mesenchymal stromal cells (MSCs) are widely studied for their immunomodulatory and tissue reparative capabilities, but clinical translation has been hampered by inconsistent efficacy and limited standardization in manufacturing. While cytokine-based priming methods, such as interferon-gamma (IFN-γ) stimulation, have shown promise in enhancing MSC potency, alternative approaches targeting distinc...

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Literature Corpus work: 1c399515-d1e3-5ee6-a363-1623425db8fa
DOI: 10.1101/2025.07.17.665406

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