Article

Infrapatellar Fat Pad-derived Mesenchymal Stem Cell-based Spheroids Enhance Their Therapeutic Efficacy to Reverse Synovitis and Fat Pad Fibrosis

2020-10-21

Abstract excerpt

<title>Abstract</title> <p>Background: To investigate the in vitro and in vivo anti-inflammatory/anti-fibrotic capacity of IFP-MSC manufactured as 3D spheroids. According to our hypothesis, IFP-MSC do not require prior cell priming to acquire a robust immunomodulatory phenotype in vitro in order to efficiently reverse synovitis and IFP fibrosis and secondarily delay articular cartilage damage in vivo. <h4>Methods...

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Literature Corpus work: 87673113-da72-537b-a78d-53cf3b9b7ea5
DOI: 10.21203/rs.3.rs-94156/v1

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