Article

Characterization of the p38α MAPK allosteric inhibition by a single chain Fv antibody

2026-01-06

Abstract excerpt

Most of the available p38α kinase inhibitors target the highly conserved ATP-binding site, thus explaining their off-target effects and toxicity. Here, we report the use of single-chain fragment variable (scFv) antibodies to identify new highly specific inhibitors. Using phage display, we selected five anti-p38α scFv antibodies among which one fully inhibited p38α kinase activity in vitro . We showed that this sc...

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Literature Corpus work: 1c3967ff-869c-54bc-ac85-8b282c74becb
DOI: 10.64898/2026.01.06.697868

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