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Article

Genetic Associations of Parkinson's Disease Clinical, Pathological, and Data-Driven Subtypes.

Genes - 13 Apr 2026

Negida Ahmed, Abouelmagd Moaz Elsayed, Hamed Belal Mohamed, Hawas Yousef, Dziri Aya, Negida Yasmin, Berman Brian D, Barrett Matthew J

Abstract excerpt

Background: Parkinson's disease (PD) is clinically heterogeneous, yet the genetic architecture underlying this heterogeneity remains incompletely understood. We examined the genetic correlates of four complementary PD subtyping frameworks: the clinical motor subtype (tremor-dominant [TD] vs. postural instability/gait difficulty [PIGD]), alpha-synuclein seed amplification assay status (SAA+ vs. SAA-), the...

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Source

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Identifiers

PMID: 42074567
DOI: 10.3390/genes17040449
PMCID: PMC13116718

Genes

GBA1
APOE
SNCA
PARK7
PINK1
PRKN
VPS35

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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