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Article

Structural analysis of the GAP-related domain from neurofibromin and its implications.

The EMBO journal - 3 Aug 1998

Scheffzek K, Ahmadian M R, Wiesmüller L, Kabsch W, Stege P, Schmitz F, Wittinghofer A

Abstract excerpt

Neurofibromin is the product of the NF1 gene, whose alteration is responsible for the pathogenesis of neurofibromatosis type 1 (NF1), one of the most frequent genetic disorders in man. It acts as a GTPase activating protein (GAP) on Ras; based on homology to p120GAP, a segment spanning 250-400 aa and termed GAP-related domain (NF1GRD; 25-40 kDa) has been shown to be responsible for GAP activity and represents the...

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Identifiers

PMID: 9687500
DOI: 10.1093/emboj/17.15.4313
PMCID: PMC1170765

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