Article

Human <i>rDNA</i> Copy Number Is Unstable in Metastatic Breast Cancers

2019-04-30

Abstract excerpt

Epigenetic silencing, including the formation of heterochromatin, silent chromosome territories, and repressed gene promoters, acts to stabilize patterns of gene regulation and the physical structure of the genome. Reduction of epigenetic silencing can result in genome rearrangements, particularly at intrinsically unstable regions of the genome such as transposons, satellite repeats, and repetitive gene clusters i...

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Literature Corpus work: 1be533e3-2d51-5f74-a332-39607b813779
DOI: 10.1101/623595

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