Article

KSHV transactivator-derived small peptide traps coactivators to attenuate MYC function and kills leukemia and lymphoma

2021-10-06

Abstract excerpt

In herpesvirus replicating cells, host cell gene transcription is frequently down-regulated because important transcriptional apparatuses are appropriated by viral transcription factors. Here, we identified a small peptide derived from the Kaposi's sarcoma-associated herpesvirus transactivator (K-Rta) sequence, which attenuates cellular c-MYC expression, reduces cell proliferation, and selectively kills cancer cel...

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Identifiers and source

Literature Corpus work: 2dc22ef1-5418-504c-a4f4-0be41123c269
DOI: 10.21203/rs.3.rs-957900/v1

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