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Article

Muscle-specific increased expression of JAG1 improves the skeletal muscle phenotype in dystrophin-deficient mice.

Proceedings of the National Academy of Sciences of the United States of America - 30 Sept 2025

de Souza Leite Felipe, Lambert Matthias R, Zhang Tracy Yuanfan, Conner James R, Paulo Joao A, Oliveira Sheldon Furtado, Guha Thakurta Sanjukta, Bowles Jennifer, Gussoni Emanuela, Gygi Steven P, Widrick Jeffrey J, Kunkel Louis M

Abstract excerpt

Therapeutic strategies for Duchenne muscular dystrophy (DMD) will likely require complementary approaches. One possibility is to explore genetic modifiers that improve muscle regeneration and function. The beneficial effects of the overexpression of Jagged-1 were described in escaper golden retriever muscular dystrophy (GRMD) dogs that had a near-normal life and validated in dystrophin-deficient zebrafish. To...

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Share to Calcium-Binding Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intercellular Signaling Peptides and Proteins

Share to Jagged-1 Protein

Share to Mice, Inbred mdx

Share to Muscle, Skeletal

Share to Muscular Dystrophy, Duchenne

Share to Serrate-Jagged Proteins

Source

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Identifiers

PMID: 40986346
DOI: 10.1073/pnas.2506437122
PMCID: PMC12501121

Genes

JAG1
DMD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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