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Article

Importance of His192 in the human thyroid hormone transporter MCT8 for substrate recognition.

Endocrinology - 1 Jul 2013

Groeneweg Stefan, Lima de Souza Elaine C, Visser W Edward, Peeters Robin P, Visser Theo J

Abstract excerpt

Monocarboxylate transporter 8 (MCT8) facilitates cellular uptake and efflux of thyroid hormone (TH). So far, functional domains within MCT8 are not well defined. Mutations in MCT8 result in severe psychomotor retardation due to impaired neuronal differentiation. One such mutation concerns His192 (H192R), located at the border of transmembrane domain (TMD) 1 and extracellular loop (ECL) 1, suggesting that this His...

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Identifiers

PMID: 23610131
DOI: 10.1210/en.2012-2225

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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