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Article

Folate-binding triggers the activation of folylpolyglutamate synthetase.

Journal of molecular biology - 27 Jul 2001

Sun X, Cross J A, Bognar A L, Baker E N, Smith C A

Abstract excerpt

Folic acid is an essential vitamin for normal cell growth, primarily through its central role in one-carbon metabolism. Folate analogs (antifolates) are targeted at the same reactions and are widely used as therapeutic drugs for cancer and bacterial infections. Effective retention of folates in cells and the efficacy of antifolate drugs both depend upon the addition of a polyglutamate tail to the folate or...

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PMID: 11501996
DOI: 10.1006/jmbi.2001.4815

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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