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Article

Zebrafish mutants identify an essential role for laminins in notochord formation.

Development (Cambridge, England) - 1 Jul 2002

Parsons Michael J, Pollard Steven M, Saúde Leonor, Feldman Benjamin, Coutinho Pedro, Hirst Elizabeth M A, Stemple Derek L

Abstract excerpt

Basement membranes are thought to be essential for organ formation, providing the scaffold on which individual cells organize to form complex tissues. Laminins are integral components of basement membranes. To understand the development of a simple vertebrate organ, we have used positional cloning to characterize grumpy and sleepy, two zebrafish loci known to control notochord formation, and find that they encode...

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Share to Cell Differentiation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

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Source

Identifiers

PMID: 12070089
DOI: 10.1242/dev.129.13.3137

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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