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MitImpact 3: modeling the residue interaction network of the Respiratory Chain subunits.

Nucleic acids research - 8 Jan 2021

Castellana Stefano, Biagini Tommaso, Petrizzelli Francesco, Parca Luca, Panzironi Noemi, Caputo Viviana, Vescovi Angelo Luigi, Carella Massimo, Mazza Tommaso

Abstract excerpt

Numerous lines of evidence have shown that the interaction between the nuclear and mitochondrial genomes ensures the efficient functioning of the OXPHOS complexes, with substantial implications in bioenergetics, adaptation, and disease. Their interaction is a fascinating and complex trait of the eukaryotic cell that MitImpact explores with its third major release. MitImpact expands its collection of genomic,...

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PMID: 33300029
DOI: 10.1093/nar/gkaa1032
PMCID: PMC7779045

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