Article

A short HBV RNA region induces RNR-R2 expression in non-cycling cells and in primary human hepatocytes

2018-10-31

Abstract excerpt

Hepatitis B virus infects non-dividing cells in which dNTPs are scarce. HBV replication requires dNTPs. To cope with this constraint the virus induces the DNA damage response (DDR) pathway culminating in RNR-R2 expression and the generation of an active RNR holoenzyme, the key regulator of dNTP levels. Previously we reported that the HBx open reading frame (ORF) triggers this pathway. Unexpectedly however, we repo...

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Literature Corpus work: 3ca561dc-a251-58bf-9bac-a96227347cc8
DOI: 10.1101/458679

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