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A positive-feedback loop between HBx and ALKBH5 promotes hepatocellular carcinogenesis

10 Jun 2021

Abstract excerpt

Abstract Background Hepatitis B Virus (HBV) contributes to liver carcinogenesis via various epigenetic mechanisms. The newly defined epigenetics, epitranscriptomics regulation, has been reported to involve in multiple cancers including Hepatocellular Carcinoma (HCC). Our previous study found that HBx, HBV encodes X protein, mediated H3K4me3 modification in WDR5-dependent manner to involve in HBV infection and...

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PMID: 34112124
DOI: 10.1186/s12885-021-08449-5

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