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Epithelial cell size dysregulation in human lung adenocarcinoma

6 Oct 2022

Abstract excerpt

Human cells tightly control their dimensions, but in some cancers, normal cell size control is lost. In this study we measure cell volumes of epithelial cells from human lung adenocarcinoma progression in situ. By leveraging artificial intelligence (AI), we reconstruct tumor cell shapes in three dimensions (3D) and find airway type 2 cells display up to 10-fold increases in volume. Surprisingly, cell size...

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PMID: 36201559
DOI: 10.1371/journal.pone.0274091

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