Article

A reference single-cell transcriptomic atlas of human skeletal muscle tissue reveals bifurcated muscle stem cell populations

2020-01-23

Abstract excerpt

<h4> Abstract </h4> Single-cell RNA-sequencing (scRNA-seq) facilitates the unbiased reconstruction of multicellular tissue systems in health and disease. Here, we present a curated scRNA-seq dataset of human muscle samples from 10 adult donors with diverse anatomical locations. We integrated ∼22,000 single-cell transcriptomes using Scanorama to account for technical and biological variation and resolved 16 disti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7bb91ec6-2007-5956-b7c0-659e593cd9e6
DOI: 10.1101/2020.01.21.914713

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A reference single-cell transcriptomic atlas of human skeletal muscle tissue reveals bifurcated muscle stem cell populationsDOI 10.1101/2020.01.21.914713Read

Single-cell transcriptional profiles in human skeletal muscleSemantic proximity Read

Delineating transcriptomic signatures of in vitro human skeletal muscle models in comparison to in vivo referencesSemantic proximity Read

Single-cell sequencing deconvolutes cellular responses to exercise in human skeletal muscleSemantic proximity Read

Single‐cell RNA‐seq reveals novel interaction between muscle satellite cells and fibro‐adipogenic progenitors mediated with FGF7 signallingSemantic proximity Read

Beyond the bulk: overview and novel insights into the dynamics of muscle satellite cells during muscle regenerationSemantic proximity Read

Muscle fibro-adipogenic progenitors from a single-cell perspective: Focus on their “virtual” secretomeSemantic proximity Read

A network-based atlas of human skeletal muscle agingSemantic proximity Read

Loss of transcriptional heterogeneity in aged human muscle stem cellsSemantic proximity Read

A Human Skeletal Muscle Atlas Identifies the Trajectories of Stem and Progenitor Cells across Development and from Human Pluripotent Stem CellsSemantic proximity Read

Identification of underexplored mesenchymal and vascular-related cell populations in human skeletal muscleSemantic proximity Read

Human Fibroblast-Myeloid cell tissue atlas across lung, synovium, skin and heartSemantic proximity Read

Single-cell transcriptome profiling of an adult human cell atlas of 15 major organsSemantic proximity Read