Article

Endothelial deletion of ADGRF5 (GPR116) promotes fibro-inflammatory EndMT and impairs adaptive thermogenesis in brown adipose tissue

2025-10-31

Abstract excerpt

<h4>Objective</h4> Brown adipose tissue (BAT) dissipates energy via non-shivering thermogenesis, and it is a promising therapeutic target for metabolic disease. While most research focuses on thermogenic adipocytes, emerging data point to critical contributions from the surrounding stromal niche. Here, we investigated the role of adhesion G protein–coupled receptors (aGPCRs) in BAT function, focusing on Adgrf5 (G...

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Literature Corpus work: 1b5c505e-9b3f-561f-a328-2e5591aa1024
DOI: 10.1101/2025.10.31.683372

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Endothelial deletion of ADGRF5 (GPR116) promotes fibro-inflammatory EndMT and impairs adaptive thermogenesis in brown adipose tissueDOI 10.1101/2025.10.31.683372Read

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