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Single-nucleus transcriptomes reveal the underlying mechanisms of dynamic whitening in thermogenic adipose tissue in goats

9 Feb 2025

Abstract excerpt

BACKGROUND: Thermogenic adipose tissue, both beige and brown, experiences whitening as animals are exposed to warmth and age, but the potential mechanisms are not fully understood. In this study, we employed single-nucleus RNA-seq to construct a cell atlas during whitening progression and identified the characteristics of thermogenic adipocytes. RESULTS: Our histological studies and bulk transcriptome gene...

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PMID: 39923114
DOI: 10.1186/s40104-025-01157-1

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