Article

DPYSL3B is a regulator of chemoresistance via DNA repair and metabolic reprogramming in prostate cancer

2025-07-07

Abstract excerpt

Prostate cancer is among the most common cancers worldwide. Aggressive, treatment-resistant subtypes including androgen receptor (AR) -negative and neuroendocrine prostate cancer, present a significant clinical challenge. Platinum-based chemotherapies, such as carboplatin, remain a treatment option for these subtypes, but their efficacy is limited due to activation of DNA damage response (DDR) pathways. Here, we r...

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Literature Corpus work: 071db915-62aa-5799-830c-9573fe39c15f
DOI: 10.1101/2025.07.03.658029

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