Article

Loss of the Y chromosome in bladder cancer drives metabolic reprogramming

2025-08-31

Abstract excerpt

Metabolic reprogramming promotes cancer aggressiveness and an immune-suppressive tumor microenvironment. Loss of the Y chromosome (LOY) drives both phenotypes in bladder cancer (BC). We investigated the hypothesis that LOY leads to metabolic reprogramming using untargeted metabolomic profiling of human BC cells and analysis of pan-cancer transcriptomic datasets. This revealed that aerobic glycolysis is activated i...

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Literature Corpus work: 09e56aa7-01d4-5110-8028-2b45c94b8b26
DOI: 10.1101/2025.08.26.672471

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