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Article

Protein O-mannosylation in animal development and physiology: from human disorders to Drosophila phenotypes.

Seminars in cell & developmental biology - 1 Aug 2010

Nakamura Naosuke, Lyalin Dmitry, Panin Vladislav M

Abstract excerpt

Protein O-mannosylation has a profound effect on the development and physiology of mammalian organisms. Mutations in genes affecting O-mannosyl glycan biosynthesis result in congenital muscular dystrophies. The main pathological mechanism triggered by O-mannosylation defects is a compromised interaction of cells with the extracellular matrix due to abnormal glycosylation of alpha-dystroglycan. Hypoglycosylation...

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Identifiers

PMID: 20362685
DOI: 10.1016/j.semcdb.2010.03.010
PMCID: PMC2917527

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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