Article

X chromosome inactivation in the human placenta is patchy and distinct from adult tissues

2019-09-28

Abstract excerpt

One of the X chromosomes in genetic females is silenced by a process called X chromosome inactivation (XCI). Variation in XCI across the placenta may contribute to observed sex differences and variability in pregnancy outcomes. However, XCI has predominantly been studied in human adult tissues. Here we sequenced and analyzed DNA and RNA from two locations from 30 full-term pregnancies. Implementing an allele speci...

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Literature Corpus work: 1afa392c-8954-50d4-a28d-f31ade381dea
DOI: 10.1101/785105

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