Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Patterns of placental development evaluated by X chromosome inactivation profiling provide a basis to evaluate the origin of epigenetic variation.

Human reproduction (Oxford, England) - 1 Jun 2012

Peñaherrera M S, Jiang R, Avila L, Yuen R K C, Brown C J, Robinson W P

Abstract excerpt

BACKGROUND: Inactivation of the maternally or paternally derived X chromosome (XCI) initially occurs in a random manner in early development; however as tissues form, a 'patchiness' will occur in terms of which X is inactivated if cells positioned near each other are clonally descended from a common precursor. Determining the relationship between skewed XCI in different tissues and in different samples from the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chorionic Villi Sampling
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Genetic Variation

Share to Infant, Newborn

Share to Placentation

Share to Pregnancy

Share to X Chromosome Inactivation

Source

Open in PubMed Open full text

Identifiers

PMID: 22431562
DOI: 10.1093/humrep/des072
PMCID: PMC3357192

Genes

IGF2
APC
CASP8
KISS1
PTPN6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Patterns of placental development evaluated by X chromosome inactivation profiling provide a basis to evaluate the origin of epigenetic variation.PMID 22431562Read ↗

X chromosome inactivation in the human placenta is patchy and distinct from adult tissuesSemantic proximity Read ↗

Somatic mutations reveal widespread mosaicism and mutagenesis in human placentasSemantic proximity Read ↗

Cross-tissue analysis of allelic X-chromosome inactivation ratios resolves features of human developmentSemantic proximity Read ↗

Inherent mosaicism and extensive mutation of human placentas.Semantic proximity Read ↗

Random X inactivation and extensive mosaicism in human placenta revealed by analysis of allele-specific gene expression along the X chromosome.Semantic proximity Read ↗

Heritability of skewed X-inactivation in female twins is tissue-specific and dependent on ageSemantic proximity Read ↗

X-chromosome inactivation patterns depend on age and tissue but not conception method in humansSemantic proximity Read ↗

Maternal bias and escape from X chromosome imprinting in the midgestation mouse placenta.Semantic proximity Read ↗

Skewed X-Chromosome Inactivation Is Common in Fetuses or Newborns Associated with Confined Placental MosaicismSemantic proximity Read ↗

Differential X Reactivation in Human Placental Cells: Implications for Reversal of X InactivationSemantic proximity Read ↗

Non-random X chromosome inactivation in mammalian cells.Semantic proximity Read ↗

The dynamics of X‐inactivation skewing as women ageSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.