Article

Inhibition of the TRIM24 bromodomain reactivates latent HIV-1

2022-09-30

Abstract excerpt

Expression of the HIV-1 genome by RNA Polymerase II is regulated at multiple steps, as are most cellular genes, including recruitment of general transcription factors and control of transcriptional elongation from the core promoter. We discovered that tripartite motif protein TRIM24 is recruited to the HIV-1 Long Terminal Repeat (LTR) by interaction with TFII-I and causes transcriptional elongation by stimulating...

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Literature Corpus work: 1adfc302-2a55-5a1d-86c2-b95da4be93dc
DOI: 10.21203/rs.3.rs-2083312/v1

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