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Article

TRIM28 promotes HIV-1 latency by SUMOylating CDK9 and inhibiting P-TEFb

17 Jan 2019

Abstract excerpt

Comprehensively elucidating the molecular mechanisms of human immunodeficiency virus type 1 (HIV-1) latency is a priority to achieve a functional cure. As current 'shock' agents failed to efficiently reactivate the latent reservoir, it is important to discover new targets for developing more efficient latency-reversing agents (LRAs). Here, we found that TRIM28 potently suppresses HIV-1 expression by utilizing...

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PMID: 30652970
DOI: 10.7554/elife.42426

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