Article
A dileucine-like sorting signal directs transport into an AP-3-dependent, clathrin-independent pathway to the yeast vacuole.
The EMBO journal - 1 May 1998
Vowels J J, Payne G S
Abstract excerpt
Transport of yeast alkaline phosphatase (ALP) to the vacuole depends on the clathrin adaptor-like complex AP-3, but does not depend on proteins necessary for transport through pre-vacuolar endosomes. We have identified ALP sequences that direct sorting into the AP-3-dependent pathway using chimer...
Topics
- Adaptor Protein Complex 3
- Alkaline Phosphatase
- Amino Acid Sequence
- Clathrin
- DNA-Binding Proteins
- Genotype
- Golgi Apparatus
- Intracellular Membranes
- Leucine
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Pyrophosphatases
- Recombinant Fusion Proteins
- Saccharomyces cerevisiae
- Sequence Alignment
- Signal Transduction
- Transcription Factors
- Vacuoles