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The Telomeric Repeats of Human Herpesvirus 6A (HHV-6A) Are Required for Efficient Virus Integration

31 May 2016

Abstract excerpt

Human herpesvirus 6A (HHV-6A) and 6B (HHV-6B) are ubiquitous betaherpesviruses that infects humans within the first years of life and establishes latency in various cell types. Both viruses can integrate their genomes into telomeres of host chromosomes in latently infected cells. The molecular mechanism of viral integration remains elusive. Intriguingly, HHV-6A, HHV-6B and several other herpesviruses harbor...

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PMID: 27244446
DOI: 10.1371/journal.ppat.1005666

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The Telomeric Repeats of Human Herpesvirus 6A (HHV-6A) Are Required for Efficient Virus IntegrationPMID 27244446Read ↗

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Unbiased optical mapping of telomere-integrated endogenous human herpesvirus 6Semantic proximity Read ↗

The latent human herpesvirus-6A genome specifically integrates in telomeres of human chromosomes in vivo and in vitroSemantic proximity Read ↗

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The putative U94 integrase is dispensable for human herpesvirus 6 (HHV-6) chromosomal integrationSemantic proximity Read ↗

Human telomeres that carry an integrated copy of human herpesvirus 6 are often short and unstable, facilitating release of the viral genome from the chromosomeSemantic proximity Read ↗

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