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Article

Purification, characterization, and identification of a sphingomyelin synthase from Pseudomonas aeruginosa. PlcH is a multifunctional enzyme.

The Journal of biological chemistry - 29 Aug 2003

Luberto Chiara, Stonehouse Martin J, Collins Elizabeth A, Marchesini Norma, El-Bawab Samer, Vasil Adriana I, Vasil Michael L, Hannun Yusuf A

Abstract excerpt

Sphingomyelin synthase is the enzyme that synthesizes sphingomyelin (SM) in mammalian cells by transferring a phosphorylcholine moiety from phosphatidylcholine to ceramide. Despite its importance, the gene and/or the protein responsible for this activity has not yet been identified. Here we report the purification, identification, and biochemical characterization of an enzymatic activity that synthesizes SM in...

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PMID: 12799377
DOI: 10.1074/jbc.M300932200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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