Article
Hyperbiofilm phenotype of Pseudomonas aeruginosa defective for the PlcB and PlcN secreted phospholipases.
Canadian journal of microbiology - 1 Sept 2017
Lewenza Shawn, Charron-Mazenod Laetitia, Afroj Shirin, van Tilburg Bernardes Erik
Abstract excerpt
Biofilms are dense communities of bacteria enmeshed in a protective extracellular matrix composed mainly of exopolysaccharides, extracellular DNA, proteins, and outer membrane vesicles (OMVs). Given the role of biofilms in antibiotic-tolerant and chronic infections, novel strategies are needed to block, disperse, or degrade biofilms. Enzymes that degrade the biofilm matrix are a promising new therapy. We screened...
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