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Article

Distinct molecular patterns of TDP-43 pathology in Alzheimer's disease: relationship with clinical phenotypes.

Acta neuropathologica communications - 29 Apr 2020

Tomé Sandra O, Vandenberghe Rik, Ospitalieri Simona, Van Schoor Evelien, Tousseyn Thomas, Otto Markus, von Arnim Christine A F, Thal Dietmar Rudolf

Abstract excerpt

The co-existence of multiple pathologies and proteins is a common feature in the brains of cognitively impaired elderly individuals. Transactive response DNA-binding protein (TDP-43) has been discovered to accumulate in limbic brain regions of a portion of late-onset Alzheimer's disease (AD) patients, in addition to amyloid-β and τ protein. However, it is not yet known whether the TDP-43 species in the AD brain...

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Identifiers

PMID: 32349792
DOI: 10.1186/s40478-020-00934-5
PMCID: PMC7189555

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