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Article

TAR DNA-Binding Protein 43 Is Associated with Rate of Memory, Functional and Global Cognitive Decline in the Decade Prior to Death.

Journal of Alzheimer's disease : JAD - 1 Jan 2021

Buciuc Marina, Tosakulwong Nirubol, Machulda Mary M, Whitwell Jennifer L, Weigand Stephen D, Murray Melissa E, Reichard R Ross, Parisi Joseph E, Dickson Dennis W, Boeve Bradley F, Knopman David S, Petersen Ronald C, Josephs Keith A

Abstract excerpt

BACKGROUND: Transactive response DNA-binding protein of 43 kDa (TDP-43) is associated with memory impairment and overall cognitive decline. It is unclear how TDP-43 contributes to the rate of clinical decline. OBJECTIVE: To determine whether cross-sectional and longitudinal cognitive and functional decline are associated with anatomical distribution of TDP-43 in the brain. METHODS: Longitudinal...

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Identifiers

PMID: 33579840
DOI: 10.3233/JAD-201166
PMCID: PMC8020877

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