Overcoming limitations to customize DeepVariant for domesticated animals with TrioTrain.

Abstract excerpt

Generating high-quality variant callsets across diverse species remains challenging as most bioinformatic tools default to assumptions based on human genomes. DeepVariant (DV) excels without joint genotyping while offering fewer implementation barriers. However, the growing appeal of a "universal" algorithm has magnified the unknown impacts when used with non-human species. Here, we use bovine genomes to assess...

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