Article
Continuous chromosome-scale haplotypes assembled from a single interspecies F1 hybrid of yak and cattle.
GigaScience - 1 Apr 2020
Rice Edward S, Koren Sergey, Rhie Arang, Heaton Michael P, Kalbfleisch Theodore S, Hardy Timothy, Hackett Peter H, Bickhart Derek M, Rosen Benjamin D, Ley Brian Vander, Maurer Nicholas W, Green Richard E, Phillippy Adam M, Petersen Jessica L, Smith Timothy P L
Abstract excerpt
BACKGROUND: The development of trio binning as an approach for assembling diploid genomes has enabled the creation of fully haplotype-resolved reference genomes. Unlike other methods of assembly for diploid genomes, this approach is enhanced, rather than hindered, by the heterozygosity of the individual sequenced. To maximize heterozygosity and simultaneously assemble reference genomes for 2 species, we applied...
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