Haplotype-resolved genomes provide insights into structural variation and gene content in Angus and Brahman cattle.

doi:10.1038/s41467-020-15848-y

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Article

Haplotype-resolved genomes provide insights into structural variation and gene content in Angus and Brahman cattle.

Nature communications - 29 Apr 2020

Low Wai Yee, Tearle Rick, Liu Ruijie, Koren Sergey, Rhie Arang, Bickhart Derek M, Rosen Benjamin D, Kronenberg Zev N, Kingan Sarah B, Tseng Elizabeth, Thibaud-Nissen Françoise, Martin Fergal J, Billis Konstantinos, Ghurye Jay, Hastie Alex R, Lee Joyce, Pang Andy W C, Heaton Michael P, Phillippy Adam M, Hiendleder Stefan, Smith Timothy P L, Williams John L

Abstract excerpt

Inbred animals were historically chosen for genome analysis to circumvent assembly issues caused by haplotype variation but this resulted in a composite of the two genomes. Here we report a haplotype-aware scaffolding and polishing pipeline which was used to create haplotype-resolved, chromosome-level genome assemblies of Angus (taurine) and Brahman (indicine) cattle subspecies from contigs generated by the trio...

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PMID: 32350247
DOI: 10.1038/s41467-020-15848-y
PMCID: PMC7190621

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