Article
Glycyrrhizin Ameliorates Fibrosis, Vasculopathy, and Inflammation in Animal Models of Systemic Sclerosis.
The Journal of investigative dermatology - 1 Mar 2017
Yamashita Takashi, Asano Yoshihide, Taniguchi Takashi, Nakamura Kouki, Saigusa Ryosuke, Miura Shunsuke, Toyama Tetsuo, Takahashi Takehiro, Ichimura Yohei, Yoshizaki Ayumi, Trojanowska Maria, Sato Shinichi
Abstract excerpt
Systemic sclerosis (SSc) is a multisystem inflammatory and vascular disease resulting in extensive tissue fibrosis. Glycyrrhizin, clinically used for chronic hepatic diseases and itching dermatitis, modulates the pathological processes of inflammation, vasculopathy, and fibrosis in human diseases and their animal models. Therefore, we investigated a potential impact of glycyrrhizin on the key pathological...
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