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Heterogeneity among Clinical Intestinal Escherichia coli Isolates upon Acquired Streptomycin Resistance.

Microbiology spectrum - 15 Jun 2023

Lopez Lacey R, Miller Claire M, Jeyachandran Joanna N, Li Chuang, Simpson Kenneth W, Arthur Janelle C

Abstract excerpt

Escherichia coli isolates from inflammatory bowel disease (IBD) patients are often multidrug resistant, including to streptomycin. Streptomycin resistance (StrR) mutations can alter bacterial behavior, which may influence intestinal disease. We generated a spontaneous StrR strain of the intestinal adherent-invasive E. coli (AIEC) strain NC101. Whole-genome sequencing revealed a single missense mutation in rpsL...

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Identifiers

PMID: 37184392
DOI: 10.1128/spectrum.03500-22
PMCID: PMC10269711

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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