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The Alternative Sigma Factor SigL Influences <i>Clostridioides difficile</i> Toxin Production, Sporulation, and Cell Surface Properties

2022-01-26

Abstract excerpt

The alternative sigma factor SigL (Sigma-54) facilitates bacterial adaptation to the extracellular environment by modulating the expression of defined gene subsets. A homolog of the gene encoding SigL is conserved in the diarrheagenic pathogen Clostridioides difficile . To explore the contribution of SigL to C. difficile biology, we generated sigL -disruption mutants ( sigL::erm ) in strains belonging to two p...

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Literature Corpus work
16795c61-c137-5bed-8fcb-235d2f7343e5
DOI
10.1101/2022.01.26.477884
Open publication

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