Article

Breast tumor Insulin-like growth factor receptor regulates cell adhesion and metastasis: Alignment of mouse single cell and human breast cancer transcriptomics

2021-09-01

Abstract excerpt

The acquisition of a metastatic phenotype is the critical event that determines patient survival from breast cancer. Several receptor tyrosine kinases have functions both in promoting and inhibiting metastasis in breast tumors. Although the insulin-like growth factor 1 receptor (IGF-1R) has been considered a target for inhibition in breast cancer, low levels of IGF-1R expression are associated with worse overall p...

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Literature Corpus work: 1a851a66-9b70-54d2-aeee-f4e60e9bf09c
DOI: 10.1101/2021.08.31.458283

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