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Article

An Integrated Genome-Wide Systems Genetics Screen for Breast Cancer Metastasis Susceptibility Genes.

PLoS genetics - 1 Apr 2016

Bai Ling, Yang Howard H, Hu Ying, Shukla Anjali, Ha Ngoc-Han, Doran Anthony, Faraji Farhoud, Goldberger Natalie, Lee Maxwell P, Keane Thomas, Hunter Kent W

Abstract excerpt

Metastasis remains the primary cause of patient morbidity and mortality in solid tumors and is due to the action of a large number of tumor-autonomous and non-autonomous factors. Here we report the results of a genome-wide integrated strategy to identify novel metastasis susceptibility candidate genes and molecular pathways in breast cancer metastasis. This analysis implicates a number of transcriptional...

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PMID: 27074153
DOI: 10.1371/journal.pgen.1005989
PMCID: PMC4830524

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