Article
Investigation of sirtuins as therapeutic targets in neurodegenerative disorders : studies on mechanisms and possible combined therapy
2020-01-01
Abstract excerpt
Up to now, current therapies for Alzheimer’s disease (AD) can treat the symptoms with modest effect and have little impact on the overall progression. AD is a complex, multifactorial disorder, featured by aggregation of toxic proteins, inflammation, oxidative stress, synaptic deficits, and cognitive decline. Thus, the multi-target therapeutic strategy is of particular interest as it uses a combination of drugs to...
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Identifiers and source
- Literature Corpus work
- 1a82f623-2db4-502c-b3d8-d815aaa8701a
- DOI
- 10.21954/ou.ro.0001177d