Article

The folding space of protein <i>β</i> 2-microglobulin is modulated by a single disulfide bridge

2021-05-20

Abstract excerpt

Protein beta-2-microglobulin ( β 2 m ) is classically considered the causative agent of dialysis related amyloidosis (DRA), a conformational disorder that affects patients undergoing long-term hemodialysis. Together with the wild type form, the Δ N 6 structural variant, and the D76N mutant, have been extensively used as model systems of β 2 m aggregation. In all of them, the native structure is stabilized by...

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Literature Corpus work: 1a74402e-d7e1-5717-8f1b-1bb61969aeaa
DOI: 10.1101/2021.05.19.444822

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The folding space of protein <i>β</i> 2-microglobulin is modulated by a single disulfide bridgeDOI 10.1101/2021.05.19.444822Read

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